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  • Title: A de novo approach to the synthesis of glycosylated methymycin analogues with structural and stereochemical diversity.
    Author: Borisova SA, Guppi SR, Kim HJ, Wu B, Penn JH, Liu HW, O'Doherty GA.
    Journal: Org Lett; 2010 Nov 19; 12(22):5150-3. PubMed ID: 20958086.
    Abstract:
    A divergent and highly stereoselective route to 11 glycosylated methymycin analogues has been developed. The key to the success of this method was the iterative use of the Pd-catalyzed glycosylation reaction and postglycosylation transformation. This unique application of Pd-catalyzed glycosylation demonstrates the breath of α/β- and d/l-glycosylation of macrolides that can be efficiently prepared using a de novo asymmetric approach to the carbohydrate portion.
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