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  • Title: Osteoclast bone resorption is enhanced in the presence of osteoblasts.
    Author: Grano M, Colucci S, Cantatore FP, Teti A, Zambonin Zallone A.
    Journal: Boll Soc Ital Biol Sper; 1990 Nov; 66(11):1051-7. PubMed ID: 2095815.
    Abstract:
    Bone resorption activity by osteoclasts has been evaluated in a co-culture system in which osteoclasts have been plated in the presence of osteoblasts. The system prevents cell-cell contact but permits diffusion of molecules through the pores of a millipore membrane that separates the two compartments in which the two cell types have been plated. Results demonstrated that osteoblasts exert a stimulatory effect over osteoclast bone resorption due to soluble molecules capable of passing through the membrane pores. The effect is specific since periosteal cells, which do not express osteoblastic characteristics, fail to induce changes in the osteoclast activity. PTH does not affect osteoblast-mediated enhancement of bone resorption, indicating that the stimulatory effect that the hormone exert in vivo occurs via a different cellular system.
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