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  • Title: 5-benzyloxytryptamine as an antagonist of TRPM8.
    Author: DeFalco J, Steiger D, Dourado M, Emerling D, Duncton MA.
    Journal: Bioorg Med Chem Lett; 2010 Dec 01; 20(23):7076-9. PubMed ID: 20965726.
    Abstract:
    5-Benzyloxytryptamine 19 was found to act as an antagonist of the TRPM8 ion-channel. For example, 19 had an IC(50) of 0.34 μM when menthol was used as the stimulating agonist. Related commercially-available tryptamine derivatives showed diminished, or no antagonist activity at TRPM8. The structural similarity of 5-benzyloxytryptamine to other literature TRPM8 antagonists was noted.
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