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  • Title: [The influence of consecutive application of B-190 preparation and interleukin-1beta on survival rate and bone marrow hematopoiesis of irradiated mice].
    Author: Grebeniuk AN, Zatsepin VV, Aksenova NV, Nazarov VB, Vlasenko TN.
    Journal: Radiats Biol Radioecol; 2010; 50(4):475-80. PubMed ID: 20968059.
    Abstract:
    The purpose of research was the experimental estimation of efficiency of consecutive application of a radioprotector B-190 and means of emergency therapy of radiating injury interleukin-1beta at acute irradiation. An estimation of treatment-and-prophylactic action of the given circuit of introduction of preparations carried out by studying 30 day-survival and average life expectancy of the lost animals, research of bone marrow hemopoiesis. It is established, that consecutive application of a radioprotector B-190 in a doze of 50 mg/kg for 15 mines up to an irradiation and interleukin-1beta in a doze of 50 mkg/kg through 15 mines after irradiating increases survival and prevents decrease in quantity of CFU-S9 at the irradiated mice in the greater degree, than their isolated introduction.
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