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  • Title: Further researches upon the inhibiting action of lycorine on ascorbic acid biosynthesis.
    Author: De Gara L, Tommasi F.
    Journal: Boll Soc Ital Biol Sper; 1990 Oct; 66(10):953-60. PubMed ID: 2096880.
    Abstract:
    Lycorine, an alkaloid extracted from Amarillidaceae, strongly inhibits the "in vivo" conversion of galactono-gamma-lactone to ascorbic acid. Lycorine seems to act as a non-competitive inhibitor on galactono-gamma-lactone oxidase, because the alkaloid rapidly forms a stable bound with the enzyme. In fact, a short incubation period with 50 microM lycorine gets a high inhibitory effect that persists when the alkaloid is removed from the incubation medium. Considering that lycorine induces scurvy-like symptoms in ascorbic acid-synthesising animals, it is reasonable to suppose that in both plants and animals lycorine inhibits the last step in the biosynthetic pathway leading from sugar to ascorbate.
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