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  • Title: Secretory antibody responses in cattle infected with foot-and-mouth disease virus.
    Author: Matsumoto M, McKercher PD, Nusbaum KE.
    Journal: Am J Vet Res; 1978 Jul; 39(7):1081-7. PubMed ID: 209706.
    Abstract:
    Antibody responses in serum, saliva, nasal secretions, or esophageal-pharyngeal fluid of foot-and-mouth disease virus-infected steers were examined by single radial immunodiffusion and mouse-neutralization tests. In steers infected with type O foot-and-mouth disease virus, high serum antibody titers were detected within 10 days after infection. Antibody was first detected in saliva at 30 days and gradually increased to a plateau at about 90 days. Small amounts of antibody continued to be secreted in saliva and in nasal secretions for at least 6 months. Antibody was not detected in esophageal-pharyngeal fluid. The major antibody activity in secretions was due to secretory immunoglobulin A as revealed by radioimmunoelectrophoresis.
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