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  • Title: Direct intracystic biopsy and pancreatic cystoscopy through a 19-gauge needle EUS (with videos).
    Author: Aparicio JR, Martínez J, Niveiro M, Cabezas A, Ruiz F, De Madaria E, Casellas JA.
    Journal: Gastrointest Endosc; 2010 Dec; 72(6):1285-8. PubMed ID: 20970789.
    Abstract:
    BACKGROUND: Histologic diagnosis of cystic pancreatic lesions (CPLs) is often difficult because of the low sensitivity of FNA and brush cytology. OBJECTIVE: To discover whether obtaining biopsy samples from the cystic wall could increase the diagnostic yield of these lesions. DESIGN: A pilot study including 2 patients with CPLs. SETTING: Endoscopy unit in a tertiary-care hospital. PATIENTS: Two women with CPLs located at the pancreatic head. INTERVENTIONS: On EUS, biopsy forceps and a SpyGlass fiberoptic were passed through a 19-gauge needle to visualize and obtain samples from the cystic wall. MAIN OUTCOME MEASUREMENTS: The histologic assessment was based on the obtained biopsy samples. RESULTS: Both CPLs were considered to be mucinous cystoadenomas, because mucinous-like cylindric epithelium without cellular atypia was observed. LIMITATIONS: Pilot study. CONCLUSIONS: Obtaining biopsy samples from the wall of a CPL is now feasible. It represents a significant advantage in the diagnostic yield of this type of lesion.
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