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  • Title: Synthesis and antibacterial activity of C-12 pyrazolinyl spiro ketolides.
    Author: Hu L, Lan P, Song QL, Huang ZJ, Sun PH, Zhuo C, Wang Y, Xiao S, Chen WM.
    Journal: Eur J Med Chem; 2010 Dec; 45(12):5943-9. PubMed ID: 20970894.
    Abstract:
    A series of C-12 pyrazolinyl spiro ketolide derivatives were designed and synthesized. The C-12 modifications involved replacing the natural C-12 methyl group in clarithromycin core with different pyrazolinyl spiros via chemical synthesis. Potential anti-bacterial activities against both erythromycin-susceptible and erythromycin-resistant bacteria were reported.
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