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  • Title: Episodic and chronic migraineurs are hypersensitive to thermal stimuli between migraine attacks.
    Author: Schwedt TJ, Krauss MJ, Frey K, Gereau RW.
    Journal: Cephalalgia; 2011 Jan; 31(1):6-12. PubMed ID: 20974609.
    Abstract:
    OBJECTIVE: To determine if migraineurs have evidence of interictal cutaneous sensitisation. SUBJECTS AND METHODS: Thermal and mechanical pain thresholds in 20 episodic migraineurs, 20 chronic migraineurs, and 20 non-migraine control subjects were compared. Quantitative sensory testing was conducted when subjects had been migraine-free for at least 48 h. Heat, cold and mechanical pain thresholds, and heat and cold pain tolerance thresholds were measured. RESULTS: Thermal pain thresholds and thermal pain tolerance thresholds differed significantly by headache group (P = 0.001). During the interictal period, episodic and chronic migraineurs were more sensitive to thermal stimulation than non-migraine controls. CONCLUSIONS: Interictal sensitisation may predispose the migraineur to development of headaches, may be a marker of migraine activity, and a target for treatment.
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