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  • Title: Isolation of neurocysticercosis-related antigens from a genomic phage display library of Taenia solium.
    Author: González E, Robles Y, Govezensky T, Bobes RJ, Gevorkian G, Manoutcharian K.
    Journal: J Biomol Screen; 2010 Dec; 15(10):1268-73. PubMed ID: 20974903.
    Abstract:
    In this study, the authors have generated a tapeworm Taenia solium genomic DNA expression library where foreign peptides/proteins were fused to N-termini of M13 cpVIII and expressed at a high copy number on the phage surface, and they showed that this library may be used in bioselection against antipathogen immune sera, allowing the identification of disease-related antigens recognizing antibodies present in clinical samples. They isolated 2 phage clones expressing T. solium-derived antigens specifically reacting with antibodies present in plasma and cerebrospinal fluid samples of neuroimaging-confirmed neurocysticercosis patients. The described antigen discovery strategy may be used for the direct identification of antigens useful for host-pathogen interaction studies as well as for the development of molecular vaccines and diagnostics.
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