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  • Title: X-linked agammaglobulinemia complicated with endobronchial tuberculosis.
    Author: Kawakami C, Inoue A, Takitani K, Kanegane H, Miyawaki T, Tamai H.
    Journal: Acta Paediatr; 2011 Mar; 100(3):466-8. PubMed ID: 20977495.
    Abstract:
    AIM: We report a case of X-linked agammaglobulinemia complicated with endobronchial tuberculosis. METHODS: We observed the patient's clinical course and analysed his data retrospectively. RESULTS: Interestingly, the T-cell proliferation activity in this patient was intact, and the CD4-positive T cells produced interferon gamma. However, the result of the quantiferon alpha-2b test was negative. CONCLUSION: The findings of this case suggest that the quantiferon alpha-2b test may not be diagnostic for tuberculosis not only in patients with T-cell disorders but also in cases with B-cell deficiencies such as X-linked agammaglobulinemia.
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