These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Hirsutalins A-H, eunicellin-based diterpenoids from the soft coral Cladiella hirsuta.
    Author: Chen BW, Chang SM, Huang CY, Chao CH, Su JH, Wen ZH, Hsu CH, Dai CF, Wu YC, Sheu JH.
    Journal: J Nat Prod; 2010 Nov 29; 73(11):1785-91. PubMed ID: 20979397.
    Abstract:
    Eight new eunicellin-base diterpenoids, hirsutalins A-H (1-8), were isolated from the soft coral Cladiella hirsuta. Their structures were elucidated by spectroscopic methods, particularly in 1D and 2D NMR experiments. The absolute configuration of 1 was determined by Mosher's method. Compounds 1, 5, and 6 have been shown to exhibit cytotoxicity toward several cancer cell lines. Compounds 2-4 and 8 were found to display significant in vitro anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein, with compound 2 also effectively reducing the level of COX-2 protein.
    [Abstract] [Full Text] [Related] [New Search]