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  • Title: Effects of sensitizers on cell respiration: 1. Factors influencing the effects of hypoxic cell radiosensitizers on oxygen utilization of tumour and cultured mammalian cells.
    Author: Biaglow JE, Greenstock CL, Durand RE.
    Journal: Br J Cancer Suppl; 1978 Jun; 3():145-9. PubMed ID: 209807.
    Abstract:
    We have investigated the effects of 24 nitrocompounds, differing in their half-reduction potential, on the respiration in vitro of Ehrlich ascites tumour cells and cultured V79 lung cells. Many drugs with redox potentials more positive than--0.35 stimulated oxygen utilization in the presence of glucose. Glucose had little effect on the inhibition of respiration by drugs with oxidation-reduction potentials more negative than--0.38. Nitrocompounds that inhibited Ehrilch cell respiration in the presence of glucose, also inhibited intracellular reduction of ferricytochrome (c+c1). Drugs that stimulated oxygen utilization also stimuated intracellular (c " c1). Drugs that stimulated oxygen utilization also stimulated intracellular reduction of ferricytochrome (c + c1). A correlation between drug oxidation-reduction potential and stimulation of oxygen utilization in KCN-inhibited cells was found.
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