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  • Title: Labdane-type diterpenoids from Leonurus heterophyllus and their cholinesterase inhibitory activity.
    Author: Hung TM, Luan TC, Vinh BT, Cuong TD, Min BS.
    Journal: Phytother Res; 2011 Apr; 25(4):611-4. PubMed ID: 20981867.
    Abstract:
    In the course of screening plants used in natural medicines as memory enhancers, a 70% ethanol extract of the aerial parts of Leonurus heterophyllus showed significant AChE inhibitory activity. Bioassay-guided fractionation and repeated column chromatography led to the isolation of a new labdane-type diterpenoids (1), named leoheteronin F, and six known compounds (2-7). The chemical structures of isolated compounds were elucidated based on extensive 1D and 2D NMR spectroscopic data. The isolates 1-7 were investigated in vitro for their anticholinesterase activity using mouse cortex AChE enzyme. Leoheteronin A (5) and leopersin G (7), which possess a 15,16-epoxy group at the side chain, were found to be potent in the inhibition of AChE.
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