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  • Title: Synthesis of 2,2-dimethyl-4-hydroxy-4-androstene-3,17-dione as an inhibitor of aromatase.
    Author: Furth PS, Rosenberger J, Marcotte PA, Robinson CH.
    Journal: J Enzyme Inhib; 1990; 4(2):131-5. PubMed ID: 2098519.
    Abstract:
    2,2-Dimethyl-4-hydroxy-4-androstene-3,17-dione (4) has been synthesized and has been shown to be a powerful competitive inhibitor of aromatase (Ki = 11.4 nM). However, compound 4 does not cause time-dependent loss of enzyme activity, in contrast to the unmethylated parent compound, 4-OHA.
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