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  • Title: Antimicrobial activity of E-4441, a representative azetidine quinolone.
    Author: Esteve M, Moros M, Coll R, Xicota MA, Llovera S.
    Journal: Drugs Exp Clin Res; 1990; 16(9):445-9. PubMed ID: 2100245.
    Abstract:
    E-4441 is a third-generation difluoroquinolone characterized by the presence in position 7 of an azetidine ring, disubstituted in position 3 by amine and methyl groups. E-4322 is another difluoroquinolone which differs from the former in having a 3-acetidinol substitution in position 7. E-4441 shows satisfactory levels of activity, both in vitro and in vivo, its activity against G(+) aerobic bacteria and anaerobic bacteria being generally notable.
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