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  • Title: Investigation of penbutolol-iron (III) complex and its spectrophotometric determination in tablets.
    Author: Radulović D, Pećanac D, Zivanović L, Agatonović-Kustrin S.
    Journal: J Pharm Biomed Anal; 1990; 8(8-12):739-42. PubMed ID: 2100616.
    Abstract:
    It has been established that penbutolol reacts with iron(III) chloride in the presence of ammonium thiocyanate to form a pink complex (2:1) that is soluble in chloroform with a maximum absorbance at 478 nm. By application of the methods of Sommer and Job involving non-equimolar solutions, the conditional stability constant (log k') of the complex at the optimum pH of 1.5 +/- 0.02 and an ionic strength of (mu) 0.14 M, was found to be 5.769. The molar absorptivity at 478 nm was 136 1 mol-1 cm-1 at pH 1.5 +/- 0.02. The validity of Beer's law has been tested in the concentration range 3-18 x 10(-4) M; the relative standard deviation (n = 8) was 1.52-3.21%. The proposed method was found to be suitable for the accurate, simple and rapid analysis of penbutolol in the bulk drug and in tablets.
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