These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Rat testis LH/hCG recptors and testosterone production after treatment with GnRH.
    Author: Huhtaniemi I, Martikainen H.
    Journal: Mol Cell Endocrinol; 1978; 11(2):199-204. PubMed ID: 210064.
    Abstract:
    Adults male rats were implanted subcutaneously for 1, 2 or 4 days with Alzet osmotic minipumps, infusing synthetic gonadotropin-releasing hormone (GnRH) at a rate of 0.1 microgram/h. Plasma LH increased significantly, reaching a maximum after 2 days treatment. Plasma and testicular testosterone levels increased to a maximum in 1 day, and decreased gradually thereafter, reaching the control level by day 4. Testicular specific [125I]hCG binding decreased gradually during the treatment, being 57% of the controls by day 4. It is concluded that changes of physiologic magnitude in circulatory LH are able to induce a significant loss of testicular LH/hCG binding capacity. Furthermore, after a short stimulatory phase there is a lack of response in testicular steroidogenesis to the elevated LH levels.
    [Abstract] [Full Text] [Related] [New Search]