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  • Title: Effects of chronic treatment with high doses of chlorpromazine on ATP and ADP hydrolysis by synaptosomal fractions from the rat caudate nucleus.
    Author: Rocha JB, Battastini AM, Sarkis JJ, Dias RD.
    Journal: Braz J Med Biol Res; 1990; 23(10):969-73. PubMed ID: 2101062.
    Abstract:
    Several studies have indicated that chlorpromazine and its metabolites affect ATP hydrolysis by brain and liver plasma membranes in vitro. The present report examines whether chronic treatment (12 days) with high doses of chlorpromazine (10 and 40 mg/kg) could affect ATP and ADP hydrolysis by synaptosomal fractions from the rat caudate nucleus. Both doses of chlorpromazine caused significant and parallel decreases (23 to 31%) in the ATP and ADP hydrolysis. The parallelism between the effects of chlorpromazine on ATP and ADP hydrolysis suggests the participation of a single enzyme (ATP diphosphohydrolase) in nucleotide hydrolysis.
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