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  • Title: [Nitrates and nitrites and the utilization of beta-carotene. II. Determining the threshold of the tolerated dose of nitrates and nitrites in the diet of rats receiving beta-carotene].
    Author: Majchrzak D, Gronowska-Senger A.
    Journal: Rocz Panstw Zakl Hig; 1990; 41(5-6):239-45. PubMed ID: 2101175.
    Abstract:
    The limit levels of potassium nitrate and sodium nitrite were determined in the diet of rats receiving orally beta-carotene. Two 30-day biological experiments were done on male Wistar rats standardized for vitamin A level in the liver. The animals were given semisynthetic diet, without vitamin A, containing definite amounts of potassium nitrate or sodium nitrite: 4.0; 4.5; 5.0; 5.5; 6.0% of the nitrate, and 0.5; 0.6; 0.7; 0.8; 0.9; 1.0% of the nitrite. The rats were given also orally two drops of an oil solution of beta-carotene in doses of 30 micrograms per rat daily. The limit of tolerance was established measuring beta-carotene utilization according to the method of balance studies and liver function test. Diet consumption and body weight of the animals were considered as well. It was found that in this experiment the limit dose, that is the dose of nitrates and nitrites over which the rats died, was 5.0% for nitrate and 0.7% for nitrite.
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