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  • Title: Oligonucleotides with pyrene fluorophore at the sugar fragment: synthesis and properties in binding to complementary polynucleotide.
    Author: Yamana K, Gokota T, Ohashi Y, Ozaki H, Kitamura M, Nakano H, Sangen O, Shimidzu T.
    Journal: Nucleic Acids Symp Ser; 1990; (22):103-4. PubMed ID: 2101883.
    Abstract:
    Oligonucleotides with 1-pyrenylmethyl substituent at the designated sugar residue were synthesized by using 5'-dimethoxytrityl 2'-(1-pyrenylmethyl)uridine 3'-phosphorobisdiethylamidite 1. It was shown that the pyrene-oligonucleotides have enhanced affinity in binding to the complementary polynucleotide sequence. The fluorescence yield and life time of the pyrene-oligonucleotide was drastically enhanced when bound by the complementary polynucleotide.
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