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  • Title: A non-hormonal therapeutic alternative in cervico-vaginal dystrophies.
    Author: Maresi MP, Baldi L, Balatresi L, Bogi G, Civello T, Cosimi A, De Santis R, Guarnotta M, Baisi F, Parente A.
    Journal: Ann Ostet Ginecol Med Perinat; 1990; 111(6):393-9. PubMed ID: 2102067.
    Abstract:
    The pharmaco therapeutic effect of polydeoxyribonucleotide vaginal suppositories in two dosages (PDRN 1,65 mg and PDRN 5 mg)* on vaginal dystrophy was studied. 40 women, aged more than forty, in surgical or physiological climacteric with cervico-vaginal dystrophy were examined. The study was carried out according to the double-blind method, randomized, between groups. Both treatments produced important ameliorations of subjective symptomatology and objective signs. No significant difference emerged between the two preparations. PDRN was proved to be a valid alternative to local hormonal therapies.
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