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  • Title: Membrane-associated cytoskeleton and transbilayer phospholipid asymmetry.
    Author: Gupta CM.
    Journal: Indian J Biochem Biophys; 1990 Dec; 27(6):365-7. PubMed ID: 2102481.
    Abstract:
    Earlier studies have suggested that the membrane-associated cytoskeleton (membrane skeleton) in erythrocytes plays a major role in maintaining the transmembrane phospholipid asymmetry. But recently, it has been proposed that an ATP-dependent aminophospholipid pump is the sole determinant of this asymmetry in these cells. A critical analysis of the published data along with some unpublished results from the author's laboratory, however, indicate that both membrane skeleton and ATP-dependent aminophospholipid pump are required for maintaining the membrane phospholipid asymmetry in native erythrocytes.
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