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  • Title: Control of melanogenesis in mouse melanoma cells of varying metastatic potential.
    Author: Niles RM, Makarski JS.
    Journal: J Natl Cancer Inst; 1978 Aug; 61(2):523-6. PubMed ID: 210294.
    Abstract:
    The control of melanin production, tyrosinase activity, and cell replication by melanocyte-stimulating hormone (MSH) and cyclic AMP (cAMP) was examined in differentially metastasizing B16 mouse melanoma variants. In B16-F1 cells (low metastatic potential), MSH or cAMP greatly elevated tyrosinase activity and melanin content while inhibiting cell replication. The same parameters in B16-F5 cells (intermediate metastatic potential) were altered to a much lesser degree, whereas B16-F10 cells (high metastatic potential) were not significantly affected by MSH or cAMP. Therefore, a correlation exists between loss of hormonal regulation and increased metastatic potential.
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