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  • Title: Identification of a cofilin-like actin-binding site on translationally controlled tumor protein (TCTP).
    Author: Tsarova K, Yarmola EG, Bubb MR.
    Journal: FEBS Lett; 2010 Dec 01; 584(23):4756-60. PubMed ID: 21036172.
    Abstract:
    Translationally controlled tumor protein (TCTP) expression is suppressed during cancer cell reversion to a non-malignant phenotype. We identified a primary sequence of TCTP with homology to ADF/cofilin. We confirm that a synthetic peptide corresponding to this sequence binds specifically to actin and is displaced from actin by cofilin. TCTP peptide has higher affinity for G-actin than F-actin and does not block actin-filament depolymerization by cofilin. These results suggest that TCTP may channel active cofilin to F-actin, enhancing the cofilin-activity cycle in invasive tumor cells. Loss of TCTP may result in sequestration of active cofilin by a monomeric pool of actin.
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