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  • Title: [Thyroid myopathy. Effect of treatment with thyroid hormones].
    Author: del Palacio A, Trueba JL, Cabello A, Gutiérrez E, Moya I, Fernández Miranda C, García Albea E, Ricoy JR.
    Journal: An Med Interna; 1990 Mar; 7(3):120-2. PubMed ID: 2103764.
    Abstract:
    We studied 20 patients afflicted with primary hypothyroidism and treated with thyroid hormone replacements, with the aim of evaluating the clinical, biochemical, EMG and anatomo-pathological effects. Cramps, as well as subjective and objective proximal muscular weakness, disappeared. Seric CPK was normalized in all cases after 1-8 weeks of treatment. EMG myopathic patterns faded away in all cases. Anatomopathological changes took longer to observe; 5 cases with new biopsy showed an isolate atrophy of type II fibers, one of them after 18 months in treatment; type I fibers had mitochondrial accumula without change compared to the initial biopsy. There was a clear tendency for the destroyed fibers to become normalized and for the structures similar to the "core" to vanish.
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