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  • Title: [Protective effects and pathogenesis of complex salvin miltiorrhiza on acute mercury poisoning in rabbits].
    Author: Jing YL, Wang YL, Yin DD, Cao BH, Zhang W, Geng F, Sun N.
    Journal: Zhongguo Ying Yong Sheng Li Xue Za Zhi; 2010 Aug; 26(3):341-4. PubMed ID: 21038687.
    Abstract:
    OBJECTIVE: To study protective effect and pathogenesis of complex salvia miltiorrhiza (DanShen) on acute mercury poisoning in rabbits. METHODS: Models of acute mercury poisoning was made in rabbits. The effect of complex salvia miltiorrhiza on blood urea nitrogen (BUN), copper-protein (CP), lactate dehydrogenase (LDH), acid phosphatase (ACP) and the malondialdehyde (MDA) in plasma, superoxide dismutase (SOD) in erythrocyte and MDA, SOD in tissues homogenate were observed. RESULTS: The administration of complex salvia miltiorrhiza after mercury injection 0.5 h and 9.5 h, decreased BUN, CP, MDA, LDH and ACP, and prevented the reduction of SOD. Compared with mercury poisoning group, the difference was statistical significant (P < 0.05, P < 0.01). CONCLUSION: It is suggested that acute mercury poisoning may result in renal damage but also multiple organ tissues, and complex salvia miltiorrhiza possesses protective effect, through stabilized membranes.
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