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  • Title: Benefits of cocrystallisation in pharmaceutical materials science: an update.
    Author: Friščić T, Jones W.
    Journal: J Pharm Pharmacol; 2010 Nov; 62(11):1547-59. PubMed ID: 21039540.
    Abstract:
    OBJECTIVES: We provide a brief overview of recent applications of cocrystals for improving the physico-chemical and materials properties of active pharmaceutical ingredients, including solubility, humidity and thermal stability, dissolution rates and compressibility for tablet formation. KEY FINDINGS: This overview illustrates the pharmaceutical applications of cocrystals, with a selection of recent examples and also attempts to foresee future developments by proposing several directions not yet explored in the area of pharmaceutical cocrystallisation. SUMMARY: Reliable strategies for the synthesis and design of pharmaceutical cocrystals have now been established, and the potential of cocrystallisation for enhancing the solid-state properties of drugs is well recognised; the field is now moving towards the understanding of cocrystal structure-property relationships, for which systematic structural studies and computational approaches will play a key role.
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