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  • Title: Antibodies from sheep immunized against Haemonchus contortus with H-gal-GP inhibit the haemoglobinase activity of this protease complex.
    Author: Ekoja SE, Smith WD.
    Journal: Parasite Immunol; 2010; 32(11-12):731-8. PubMed ID: 21039613.
    Abstract:
    Highly protective intestinal cell membrane antigens have been prepared from Haemonchus contortus, an important blood feeding nematode which parasitizes sheep and goats. One such antigen, H-gal-GP, is a glycoprotein complex containing predominantly digestive proteases. This study showed that H-gal-GP readily digested ovine haemoglobin and albumin, the two most abundant proteins in the parasite's blood meal. It was found that adding protective antibodies from H-gal-GP immunized sheep to the H-gal-GP catalysed haemoglobin digestion reaction, reduced the rate by 70-90% at pH 5·0. This reduction was only 30% when nonprotective IgG from sheep immunized with denatured H-gal-GP was added and IgG from worm-free sheep had no effect. These results support the theory that the mechanism of protection in sheep vaccinated with H-gal-GP is by specific antibodies impairing the parasites ability to digest its blood meal.
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