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Title: [Treatment of neuroendocrine tumours of the gastrointestinal tract]. Author: Hansen CP, Langer S, Frevert S, Mortensen J, Kjaer A, Knigge U. Journal: Ugeskr Laeger; 2010 Oct 25; 172(43):2942-5. PubMed ID: 21040671. Abstract: The prognosis of neuroendocrine tumours of the gastrointestinal tract and pancreas is difficult to estimate due to their heterogeneous nature. Survival without dissemination may reach 90%, while metastases reduce the 5-year survival to less than 50%. Radical surgery offers the only possibility of cure. Palliative therapy includes surgery and intra-arterial embolization of hepatic metastases, chemotherapy, biotherapy with interferon-alpha and radionuclear treatment. Tumour-targeted therapy with tyrosine kinase inhibitors, mammalian target of rapamycin inhibitors or monoclonal antibodies are under investigation in phase-III studies.[Abstract] [Full Text] [Related] [New Search]