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  • Title: Serious complications after infective endocarditis.
    Author: Le V, Gill S.
    Journal: Dan Med Bull; 2010 Oct; 57(10):A4192. PubMed ID: 21040681.
    Abstract:
    INTRODUCTION: The objective of the present study was to review all cases of infective endocarditis at our hospital between 2002 and 2006 concerning the bacteriological aetiology and outcomes. MATERIAL AND METHODS: This is a retrospective study based on medical records from patients in whom the discharge diagnosis infective endocarditis was established according to Duke's criteria. The study included 151 patients. RESULTS: The most prominent risk factors were valvular prostheses (22%) and known valvular disease (21%). The median diagnostic delay was four days (0-103 days). The most prominent causative microorganism was Staphylococcus aureus (41%), followed by non-haemolytic streptococci (21%), haemolytic streptococci (10%) and enterococci (14%). The most frequently occurring complications were embolic events (29%) and valvular insufficiency (26%). Renal insufficiency, multi-organic failure and disseminated intravascular coagulation occurred in 36 patients (24%). Half of the patients (51%) received surgical treatment. The overall in-hospital mortality was 29%, and 16% had severe sequelae at discharge. High mortality was found, particularly in the elderly patients, in patients who had staphylococcal endocarditis and in patients with valvular prosthesis. CONCLUSION: Despite considerable progress in diagnostics and treatment facilities, infective endocarditis remains a serious disease with long diagnostic delay times, high complication rates and a high mortality.
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