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  • Title: Design of a novel class of biphenyl CETP inhibitors.
    Author: Lu Z, Napolitano JB, Theberge A, Ali A, Hammond ML, Tan E, Tong X, Xu SS, Latham MJ, Peterson LB, Anderson MS, Eveland SS, Guo Q, Hyland SA, Milot DP, Chen Y, Sparrow CP, Wright SD, Sinclair PJ.
    Journal: Bioorg Med Chem Lett; 2010 Dec 15; 20(24):7469-72. PubMed ID: 21041082.
    Abstract:
    A new class of CETP inhibitors was designed and prepared. These compounds are potent both in vitro and in vivo. The most active compound (12d) has shown an ability to raise HDL significantly in transgenic mouse PD model.
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