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  • Title: Antibacterial prenylated acylphloroglucinols from the fern Elaphoglossum yungense.
    Author: Socolsky C, Arena ME, Asakawa Y, Bardón A.
    Journal: J Nat Prod; 2010 Nov 29; 73(11):1751-5. PubMed ID: 21043474.
    Abstract:
    Seven new prenylated acylphloroglucinols, yungensins A-G, were isolated from the diethyl ether extract of the scaly rhizomes and roots of an Argentine collection of the fern Elaphoglossum yungense. All the compounds contained a geranyl group attached to the filicinic acid-type residue. The diethyl ether extract and yungensins A-F displayed antibacterial effects against Staphylococcus aureus and Pseudomonas aeruginosa with MICs ranging from 10 to 200 μg/mL. All tested acylphloroglucinols, except for yungensin D, caused bacteriolysis of S. aureus at MBC or higher doses (50-200 μg/mL). At 10 μg/mL, the ether extract as well as yungensins A, B, and D-F altered the biofilm production in both microoganisms.
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