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  • Title: Neonatal treatment with phenobarbital, zixoryn and chloramphenicol lack of imprinting effect of zixoryn on microsomal enzyme activities.
    Author: Vas A, Szabó I, Kurcz M, Bence J.
    Journal: Acta Physiol Hung; 1990; 76(4):313-7. PubMed ID: 2104498.
    Abstract:
    Two potent microsomal enzyme inducing agents, phenobarbital and flumecinol (Zixoryn) as well as the microsomal enzyme inhibitor chloramphenicol (Chlorocid) were given subcutaneously to newborn rats in the first 5 days of their life. Microsomal cytochrome P-450 and b5 content and various cytochrome P-450 and P-448 dependent enzyme activities were measured at the age of 20 weeks. Phenobarbital had positive imprint effect on aminopyrine N-demethylase activity in female and on aniline hydroxylase activity in male rats. Flumecinol had no imprint effect. Chloramphenicol had a positive imprint on aniline hydroxylase activity in male rats. Sex differences in microsomal enzyme activities were not affected by the xenobiotics used.
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