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  • Title: [Expression of MDR1-mRNA, MRP-mRNA and LRP-mRNA in patients with non-small cell lung cancer].
    Author: Yang J, Dai W, Shi T, Wei X.
    Journal: Zhongguo Fei Ai Za Zhi; 2001 Jun 20; 4(3):175-7. PubMed ID: 21047470.
    Abstract:
    BACKGROUND: To investigate the expression of multidrug resistance (MDR1), multidrug resistance-associated protein (MRP) and lung resistance protein (LRP) genes in patients with non-small cell lung cancer (NSCLC). METHODS: Expression of MDR1, MRP and LRP genes was detected in 30 NSCLC patients by RT-PCR method. RESULTS: The positive rates of MDR1 expression were 40% and 16.67% respectively in lung cancer tissues and normal lung tissues (P=0.045), and it was not associated with the degree of cell differentiation, histological classification and the clinical stage. The positive rates of MRP expression were 43.33% and 26.67% respectively in lung cancer tissues and normal lung tissues. Its expression was related to degree of cell differentiation (P=0.03), but not to the histological classification and the clinical stage. LRP expression of lung cancer tissues (56.67%) was much higher than that of normal tissues (P=0.0004), and it was not associated with degree of cell differentiation, histological classification and the clinical stage. Of the 30 lung cancer specimens, 7 expressed all the three kinds of genes, and 10 expressed none of them. The coincident rate was 56.67%. CONCLUSIONS: The results suggest that MDR1, MRP and LRP gene may play important roles in drug resistance in NSCLC.
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