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  • Title: Intra-articular sodium hyaluronate injections in the osteoarthritic ankle joint: effects, safety and dose dependency.
    Author: Witteveen AG, Sierevelt IN, Blankevoort L, Kerkhoffs GM, van Dijk CN.
    Journal: Foot Ankle Surg; 2010 Dec; 16(4):159-63. PubMed ID: 21047602.
    Abstract:
    BACKGROUND: To determine the efficacy, safety and dose dependency of intra-articular Orthovisc(®) hyaluronic acid injections in the ankle. METHODS: A prospective single blinded study in patients with symptomatic ankle-osteoarthritis. Patients were randomly allocated to 1, 2, 3 ml, or 3 weekly injections of 1 ml (3 × 1 ml). Primary outcome was 'pain during walking' at 15 weeks measured on a 100mm VAS. RESULTS: Twenty-six patients (ITT) participated. The 3 × 1 ml dose group showed statistically significant decreases at week 7 for 'pain during walking' and 'pain at rest' (p=0.046). At week 15 decreases were significant for 'pain at rest' (p=0.046). There was no significant decrease of VAS-scores in any of the single dose groups. Seven patients experienced temporary local swelling and increased pain in the injected ankle. CONCLUSIONS: Orthovisc(®) viscosupplementation in the ankle joint is effective and well tolerated. The 3 × 1 ml dose regimen shows the best results.
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