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  • Title: Effect of somatostatin analogues and 17-alpha-dihydroequilin on rat brain opiate receptors.
    Author: Pugsley TA, Lippmann W.
    Journal: Res Commun Chem Pathol Pharmacol; 1978 Jul; 21(1):153-6. PubMed ID: 210485.
    Abstract:
    Two somatostatin analogues (SA) and 17-alpha-dihydroequilin (E) inhibited the stereospecific binding of 3H-naloxone in vitro to rat brain opiate receptors in the absence of sodium. The addition of sodium indicated the SA to be greater or similar in potency to somatostatin as opiate agonists and E to be an opiate antagonist. The results indicate that SA and certain steroids may affect endorphin containing neurons.
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