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  • Title: Cervical large cell neuroendocrine carcinoma with cytologic presentation: a case report.
    Author: Niwa K, Nonaka-Shibata M, Satoh E, Hirose Y.
    Journal: Acta Cytol; 2010; 54(5 Suppl):977-80. PubMed ID: 21053581.
    Abstract:
    BACKGROUND: Large cell neuroendocrine carcinoma (LCNEC) is a rare and aggressive cervical neoplasm. Few cytologic or colposcopic findings of LCNEC have been reported. CASE: A 37-year-old woman, gravida 6, para 4, presented with vaginal bleeding for 3 months. The cervical smears showed cells dispersed as single cells or arranged as loosely cohesive sheets or glandlike aggregate and the nuclear size was almost 3-5 times larger than that of small lymphocytes. The cytologic, pathologic and immunohistochemical examinations suggested LCNEC. The patient underwent a radical hysterectomy and then received radiation and systemic chemotherapy. CONCLUSION: Cytologic and colposcopic findings for LCNEC of the uterine cervix are reported. Patients with LCNEC have poor prognoses. Early diagnosis of the tumor is important.
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