These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Pulsatile LH secretion and hypothalamic-pituitary function in amenorrheic women].
    Author: Obara M, Mizunuma H, Honjo S, Ando K, Ibuki Y, Igarashi M.
    Journal: Nihon Sanka Fujinka Gakkai Zasshi; 1990 Jan; 42(1):23-9. PubMed ID: 2105364.
    Abstract:
    In order to evaluate hypothalamic-pituitary function and pulsatile LH secretion in 42 amenorrheic women, blood was collected every 20 min. for 6 hrs. The mean LH pulse frequency (LH-pf) of women with a normal cycle, PCO and hyperprolactinemia was 3.4 +/- 0.5, 5.2 +/- 0.8, and 1.6 +/- 1.0/6 hrs, respectively. Hypothalamic amenorrhea (HA) with no progesterone withdrawal bleeding showed a lower frequency of LH secretion. As LH-pf in HA with progesterone withdrawal bleeding (HAI) ranged from 0 to 5/6 hrs, the HAI group was divided into 2 groups according to whether their LH-pf was less than 3.4/6 hrs (HAIa) or more (HAIb). Pituitary response to 100 micrograms of LH-RH in HAIb was much lower than in HAIa and PCO. On the other hand, in HA with LH-pf less than 3.4, LH-pf showed a significant correlation with basal LH and FSH levels and the LH increase to 100 micrograms of LH-RH, while in HA with LH-pf greater than or equal to 3.4, LH-pf had no significant correlation with them. In PCO, a high LH pulse frequency and amplitude and LH response to 100 micrograms of LH-RH were shown, but the LH increase to 100 micrograms of LH-RH was significantly reduced with the increase in LH-pf. Pituitary response to 100 micrograms of LH-RH in women with hyperprolactinemia was maintained despite low LH-pf. These results suggest that the analysis of pulsatile LH secretion is very helpful in evaluating hypothalamic-pituitary function in amenorrheic women.
    [Abstract] [Full Text] [Related] [New Search]