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  • Title: The effects of age on lipopolysaccharide-induced cognitive deficits and interleukin-1β expression.
    Author: Tarr AJ, McLinden KA, Kranjac D, Kohman RA, Amaral W, Boehm GW.
    Journal: Behav Brain Res; 2011 Mar 01; 217(2):481-5. PubMed ID: 21055422.
    Abstract:
    An acute LPS challenge immediately following day 1 of shuttlebox training triggered exacerbated central IL-1β production and disrupted memory consolidation and/or further acquisition of the task in 18-month-old mice, compared to 4-month-old controls. These deficits cannot be attributed to alterations in sickness behavior. The findings suggest that age and immune activation combine to impair learning and memory consolidation processes, and that increased central IL-1β production may play a role.
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