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  • Title: Origin and evolution of the ligand-binding ability of nuclear receptors.
    Author: Markov GV, Laudet V.
    Journal: Mol Cell Endocrinol; 2011 Mar 01; 334(1-2):21-30. PubMed ID: 21055443.
    Abstract:
    The origin of the ligand-binding ability of nuclear receptors is still a matter of discussion. Current opposing models are the early evolution of an ancestral receptor that would bind a specific ligand with high affinity and the early evolution of an ancestral orphan that was a constitutive transcription factor. Here we review the arguments in favour or against these two hypotheses, and we discuss an alternative possibility that the ancestor was a ligand sensor, which would be able to explain the apparently contradictory data generated in previous models for the evolution of ligand binding in nuclear receptors.
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