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  • Title: New diterpenoids and cytotoxic and anti-inflammatory diterpenoids from Amentotaxus formosana.
    Author: Chen HL, Lin KW, Gan KH, Wang JP, Won SJ, Lin CN.
    Journal: Fitoterapia; 2011 Mar; 82(2):219-24. PubMed ID: 21055452.
    Abstract:
    Two new abietane diterpenoids, ramentoxide (1) and ramentoxidone (2) and a new icetexane diterpenoid, amentonone (3) were isolated from the barks of Amentotaxus formosana. The structures of 1-3 were determined by spectroscopic methods. Known compounds brevitaxin (4), and (+)-ferruginol (5) and ent-kaur-16-en-15-one (6) isolated from this plant revealed potent cytotoxic activity against human breast adenocarcinoma cells, MCF-7 cells with an IC(50) value of 0.08 ± 0.05 μg/mL, and significant anti-inflammatory activities, respectively.
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