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  • Title: Induction of tubulin polymerization and apoptosis in malignant mesothelioma cells by a new compound JBIR-23.
    Author: Hwang JH, Takagi M, Murakami H, Sekido Y, Shin-ya K.
    Journal: Cancer Lett; 2011 Jan 28; 300(2):189-96. PubMed ID: 21055871.
    Abstract:
    Malignant pleural mesothelioma (MPM) is a highly aggressive tumor with a poor prognosis. Thus, novel therapeutic agents need to be developed for treating it. We recently reported the isolation of the novel anti-MPM compound designated as JBIR-23 from Streptomyces sp. AK-AB27. In this study, JBIR-23 exerted its cytotoxic effect on MPM cells by promotion of tubulin polymerization and G₂/M arrest, which was followed by apoptosis induction via the caspase pathway through phosphorylation of p38 mitogen-activated protein kinase and c-jun N-terminal kinase. Furthermore, in vivo analysis demonstrated that JBIR-23 prevented tumor growth in tumor-bearing nude mice without evident side effects.
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