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  • Title: Serology of celiac disease in gluten-sensitive ataxia or neuropathy: role of deamidated gliadin antibody.
    Author: Rashtak S, Rashtak S, Snyder MR, Pittock SJ, Wu TT, Gandhi MJ, Murray JA.
    Journal: J Neuroimmunol; 2011 Jan; 230(1-2):130-4. PubMed ID: 21056914.
    Abstract:
    The role and relevance of deamidated gliadin antibodies specific for celiac disease in gluten-sensitive ataxia/neuropathy is unknown. We investigated the association of celiac-specific serology with gluten-sensitive ataxia/neuropathy, in patients with and without gliadin-induced enteropathy. 51 patients with unexplained ataxia/neuropathy suspected to have gluten sensitivity were included in the study and their serum celiac-specific markers were measured. Deamidated gliadin-IgA (83% vs. 22%), deamidated gliadin-IgG (50% vs. 3%), tissue transglutaminase-IgA (78% vs. 11%), and anti-endomysial-IgA (70% vs. 0%), were significantly more positive in ataxia/neuropathy patients with celiac disease versus those without enteropathy (P<0.001). Our findings suggest that the serological profile of gluten-sensitive ataxia/neuropathy without intestinal involvement lacks the recognition of deamidated gliadin and tissue transglutaminase epitopes.
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