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  • Title: Derivatization reagents in liquid chromatography/electrospray ionization tandem mass spectrometry.
    Author: Santa T.
    Journal: Biomed Chromatogr; 2011 Jan; 25(1-2):1-10. PubMed ID: 21058414.
    Abstract:
    Liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) is one of the most prominent analytical techniques owing to its inherent selectivity and sensitivity. In LC/ESI-MS/MS, chemical derivatization is often used to enhance the detection sensitivity. Derivatization improves the chromatographic separation, and enhances the mass spectrometric ionization efficiency and MS/MS detectability. In this review, an overview of the derivatization reagents which have been applied to LC/ESI-MS/MS is presented, focusing on the applications to low molecular weight compounds.
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