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  • Title: Lycopodium alkaloids from Huperzia serrata.
    Author: Yang YF, Qu SJ, Xiao K, Jiang SH, Tan JJ, Tan CH, Zhu DY.
    Journal: J Asian Nat Prod Res; 2010 Nov; 12(11):1005-9. PubMed ID: 21061224.
    Abstract:
    A new lycopodane-type Lycopodium alkaloid, 6α-hydroxy-5,15-oxide-lycopodane (1), and seven known alkaloids were isolated from the whole plants of Huperzia serrata. Their structures were elucidated by means of spectroscopic methods. 12-Deoxyhuperzine O (2) was reported as a naturally occurring alkaloid for the first time, and showed an antagonist effect on the N-methyl-d-aspartate receptor with an IC(50) value of 0.92 μM.
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