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  • Title: [Skin spots, skin nodules, gangrene of the toes].
    Author: Mengden T, Marincek B, Zynamon A, Vetter W.
    Journal: Schweiz Rundsch Med Prax; 1990 Jan 23; 79(4):74-8. PubMed ID: 2106156.
    Abstract:
    A 42-year-old man with multiple cutaneous neurofibromacules, café-au-lait and gangrene of toes was diagnosed having neurofibromatosis in 1976. An aortography performed because of severe hypertension had shown a coarctation and bilateral renal artery stenosis in 1982. Conservative antihypertensive therapy with an ACE-inhibitor, a vasodilatating agent and a diuretic resulted in gradual normalisation of blood pressure values. A recent follow-up revealed minimal progression of neurofibromatosis and hypertensive lesions documenting a benign course for over 13 years.
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