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  • Title: Interleukin 2 (IL-2)-induced tyrosine phosphorylation of IL-2 receptor p75.
    Author: Asao H, Takeshita T, Nakamura M, Nagata K, Sugamura K.
    Journal: J Exp Med; 1990 Mar 01; 171(3):637-44. PubMed ID: 2106566.
    Abstract:
    We have recently established a mAb named TU11 mAb specific for the p75 subunit of human IL-2 receptor (IL-2R). The present study using TU11 mAb demonstrates the IL-2-induced phosphorylation of IL-2Rp75 on tyrosine residues in IL-2-dependent T cells. The tyrosine phosphorylation is mediated by the high affinity IL-2R, correlates with the IL-2-induced cell growth, and rapidly increases during the first 5 min of IL-2 stimulation. Phosphorylation of serine and threonine residues of IL-2Rp75 is also detected, but its IL-2 dependency is not significant during at least the first 5 min. These results suggest some roles of a tyrosine kinase associated with IL-2Rp75 in the IL-2-induced signal-transducing pathway.
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