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  • Title: Enantioselective Friedel-Crafts alkylation of indole derivatives catalyzed by new Yb(OTf)3-pyridylalkylamine complexes as chiral Lewis acids.
    Author: Grach G, Dinut A, Marque S, Marrot J, Gil R, Prim D.
    Journal: Org Biomol Chem; 2011 Jan 21; 9(2):497-503. PubMed ID: 21069238.
    Abstract:
    New Yb(OTf)(3)-pyridylalkylamine complexes have been employed as chiral Lewis acids in the enantioselective Friedel-Crafts alkylation of indole derivatives with trifluoropyruvates. The influence of the substituents as well as the configuration of the ligands have been studied and allowed us to reach enantiomeric excesses up to 83%.
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