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  • Title: Spectrum of efficacy of valproate in 55 patients with rapid-cycling bipolar disorder.
    Author: Calabrese JR, Delucchi GA.
    Journal: Am J Psychiatry; 1990 Apr; 147(4):431-4. PubMed ID: 2107762.
    Abstract:
    In order to explore valproate's spectrum of efficacy in rapid-cycling bipolar disorder, 55 patients underwent a prospective, open, 7.8-month trial designed to assess the drug's acute and prophylactic properties. Twenty patients received monotherapy, and 35 received combination therapy. Moderate to marked acute antidepressant responses were seen in 47% of the patients, prophylactic antidepressant responses in 76%, acute antimanic responses in 91%, prophylactic antimanic responses in 94%, acute responses in mixed states in 85%, and prophylactic responses in mixed states in 93%. Consistent with other anticonvulsant literature, these data suggest that valproate has marked antimanic and mixed state efficacy, but minimal to moderate antidepressant properties.
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